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                                     = CVm(y)C7
        Here C=(X'X)-'X'.   Since  Vm(y)=Vm(~)=a~I,then
                               Vm(b) = m2(XTX)-'                              (5)
        It is understood from Eqn.5 that the variance-covariance matrix  Vm(b)  consists of the components
                                           is
        a2 and  (X'X)-' .  As mentioned above,  a2 the variance of the random errors that are related to
        the characteristics of the response y; thus it cannot be controlled.  On the other hand  (X'X)-'  is
        determined  by  the  combination  of  the  design  variables.  Therefore,  the  minimization  of  each
        component of  Vm(b) is possible if we minimize the dispersion of  (X'X)-' . In this way, estimation
        of  at  a high  level  of  accuracy  can be  realized.  This  is  the  principle upon  which  the  design  of
        experiment is based.   Taking advantage of the advancement of recent computer technology, a few
        numerical approaches of the design of experiment are proposed.  In the design of experiment using a
        Computer, a large number of candidate combinations of design variables are prepared beforehand, and
        the minimum number of combinations are selected from them by using the optimum criterion.  In this
        paper, the D-optimal design, Khuri & Cornell (1 996), is used.  The D-optimal design is a method that
        determines  a  combination of  design  variables  which  maximizes  the  determinant  of  the  matrix
        M(= XT X / k) , which is called the moment matrix.  In this method, by normalizing the coordinate of
        the design variable between -1  to  1, D-efficiency ( DH ), which is the corrected value of the moment
        matrix, is used as the criterion:
                                      (Det[XTXP"
                                 Def  =
                                          k
        where p+l is the number of unknown parameters in Eqn.3.
        Each  (XrX)-'  component decreases relatively if we choose the combination of the design variable
        which  maximizes  the  D@; therefore,  accurate  parameters  for  the  polynomial  equation  can  be
        obtained.

        2.2 Approximation of mpnse sdace wing p&nomal
        In the actual design problems, the true solution may fluctuate or be discontinuous.  In such cases, a
        decrease of the  search accuracy  or  failure of  the  search algorithm is  often brought  about  if  the
        solution-search method  uses the  gradient  of the  response
        surface.  In  response  surface  methodology,  on  the  other         I
        hand, the least squares method using the polynomial as seen
        in  Eqn.2  is  utilized  and  an  alternative solution having  a
        smooth  surface  is obtained.  The search efficiency of the
        optimum solution is very good, since the optimization in the
        alternative response surface finishes almost  in a  moment.
        Moreover, this methodology has the advantage that it would  P
        be able to easily grasp the general property of the response   z
        by obtaining the approximate response surface which filters  ;
        the small discontinuity or  fluctuations which  are, in some
        cases,  inevitable  (e.g.,  measuring  errors  in  model
        experiments,  etc.).  This advantage is very effective in the
        initial  design  stage.   If  we  consider  the  approximate
        polynomial to be a Taylor series expansion of the solution, it
        may be said that an approximation with sufficient accuracy   Figure 1:T.B.H.D.model
        is possible  using  a low-order  polynomial  if  the region of
        interest is narrow.  To approximate the response in a wider
        region,  the  introduction of  higher order  terms in the polynomial  is considered.  However,  if  we
        introduce higher terms, a rapid increase of computing time and unstable solutions are easily anticipated.
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