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146   Cha p te r  S i x


                     Here  A  is the system availability in operation mode  i for the  jth
                           i
                     design, and x  is the mode i’s ratio of actual to maximum capacity for
                                i
                     the jth design.
                     6.6.2 Optimization
                     Within the optimization framework for integrating RAM into process
                     synthesis, the mathematical model aims to minimize the life-cycle
                     cost. In its general form (Yin and Smith, 2008), the optimization
                     problem can be summarized as follows:

                        Minimize: the objective function (expected cost)
                        Subject to: process model constraints, preventive maintenance
                          constraints, process system availability constraints

                     The objective function is usually formulated as
                     Annual cost =  Annualized capital cost + Annualized
                                 operational cost + Annual lost production
                                 penalty + Other costs                     (6.7)


                6.7   Pressure Drop and Heat Transfer Enhancement in
                      Process Integration

                     Various factors—including flow rate, composition, temperature, and
                     phase—can affect heat capacity  C . Another factor that should be
                                                   p
                     taken into account is pressure. Polley, Panjeh Shahi, and Jegede (1990)
                     extended the Heat Exchanger Network (HEN) targeting procedure
                     by considering pressure drop. They used the following relationship
                     between the pressure drop ΔP, the heat transfer coefficient h, and the
                     heat transfer area A:

                                               P    KAh m                  (6.8)
                     where K is a pressure-drop relationship constant and m reflects the
                     heat exchanger’s tube- and shell-side–specific coefficients. The
                     allowable pressure drop (rather than the heat transfer coefficient) is
                     specified for each stream. Then the heat transfer coefficients are
                     calculated iteratively to minimize the total area. Thus, when
                     approaching area targets the design is modified based on the fixed
                     pressure drops rather than fixed film coefficients.
                        Ciric and Floudas (1989) suggested a Mathematical Programming–
                     based, two-stage approach to HEN retrofits that includes a match
                     selection stage and an optimization stage. The match selection
                     stage uses an MILP transshipment model to select process stream
                     matches and match assignments. The optimization stage uses an NLP
                     formulation to optimize the match order and flow configuration of
                     matches.
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