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                     multiple utilities targeting (Cont.):  optimal process synthesis (Cont.):
                       pinch technology and, 61–69   steps for composition of maximal
                       utility placement options, 63–69  structure, 169
                       utility placements, GCCs and, 61–62  synthesis of green biorefineries
                     multistream heat exchangers, 4      and, 171–173
                                                   optimal workflow structures:
                          N N                        P-graph, 171
                     network evolution:              plausible activities for, 170
                                                     synthesis of heterogeneous
                       loops, paths and, 93              flowsheets and, 169–171
                       splitting and advanced tick-off   optimality conditions:
                           with, 92                  global search algorithms, 28–29
                       splitting procedure above pinch, 92  local search algorithms, 28
                     network optimization, 8       optimality problems, stochastic
                     Network Pinch method, 16–17, 21   search methods for solving,
                     network/topology data identification,   32–33
                         34–35                     optimization:
                     Newton method search algorithm, 30  availability, reliability and, 186–190
                     NLP. See nonlinear programming   combined PI and, 165–190
                         (NLP) models                emissions/effluents minimized
                     nodes, of MILP, 31–32               and, 183–186
                     nonisothermal stream mixing, 287  methods with optimal process
                     nonisothermal utilities, 65–66      synthesis, 167
                     Nonlinear and Mixed-Integer     network, 8
                         Optimization: Fundamentals and   optimal design of industrial
                         Applications (Floudas), 315     processes and, 315
                     nonlinear programming (NLP)     optimal process synthesis and,
                         models:                         167–176
                       absence of integer variables and, 27  optimal scheduling for throughput,
                       convexity case-by-case evaluation, 28  profit, security and, 179–183
                       equation construction, 35     optimal synthesis of energy
                       mass balances/problems, 36        systems and, 176–179
                       penalty methods for solving   process synthesis and role of,
                           constrained, 31               165–166
                       simplex algorithm for         summary, 190
                           problem-solving, 29       tools for efficient implementation of
                     numerical targeting, 56–60          PI, 166–167
                                                     water minimization via
                          O O                            mathematical, 118–122
                     objective function, 25        optimization, sustainable industry:
                     object-oriented modeling, 38–39  conferences, 309–310
                     oil crises (1973–1974, 1979), 14  journals, 310
                     onion diagram, 48               projects, 311
                     open-source DWSIM chemical process   service providers, 310–311
                         simulator, 24             optimization packages,
                     operating costs, 290–292          general-purpose:
                     optimal process synthesis:      Frontline Systems, 209
                       azeotropic distillation systems and,   GAMS, 35, 206–207
                           173–176                   ILOG ODM, 209–210
                       classification of optimization   LINDO, 208–209
                           methods, 167              MIPSYN, 207–208
                       heterogeneous flowsheets and, 169–  software tools, 206–210
                           171                     optimization technology:
                       optimization and, 167–176     application, 9
                       reaction network synthesis and,   flowsheeting simulation tools, 7
                           167–169                   HENs retrofit, 16–17
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