Page 381 - Vibrational Spectroscopic Imaging for Biomedical Applications

Index 355

ILC, 173 Lin, Mercedes, 342
Imaging-PAM fluorometer, 44 Line mapping, 158–159, 273–275
Immunohistochemical analysis, 71 Linear array detector, 38
In vivo confocal Raman Linear discriminant analysis (LDA),
microspectroscopy, 282 184–186
In vivo kinetics of pathological Lipofuscin fluorescence imaging, 211,
mineralization, 55 214, 215
Independent component analysis Liquid crystal tunable filter (LCTF),
(ICA), 278 159–160
Infrared evanescent imaging. See Liquid-crystal tunable filter (LCTF),
Evanescent wave imaging 271, 273, 275
Inkless fingerprinting technologies, 117 LNCap-FGC, 81
Instrument response, 166, 167 Loading history, 314
Instrument response correction, 166–167 Logistic regression, 184
Integrated point spread function, 111 Low-contrast interface, 112
Invasive ductal carcinoma (IDC), 173 Low-e microscope slides, 60
Invasive lobular carcinoma (ILC), 173 Low-E slides, 112
IRENI, 29, 31–36 LS fitting, 278
beamline design and LSA, 184
implementation, 32–35 Lung fibroblast cells, 242–245
initial flow cell measurements, 47–48 Lungs, 239–241
initial measurements, 35–36
IRENI beam line with a focal plane M M
array, 38
Isenor, M., 152 Macro ATR imaging, 117–118
Macula lutea, 194
Macular pigment (MP), 196–215
J J human subjects, 211–215
measurements, 199–204
J3 criterion, 175 methodology/validation
Jablonsky diagram, 268 experiments, 205–211
Jilkine, K., 152 optical properties of carotenoids,
Julian, Robert, 151 196–199
proof of principle studies, 200
Magnetic resonance imaging (MRI), 133
K K Mahalanobis distance (MD), 174–177,
K-means cluster analysis (KCA), 181
183–184, 228, 233 Malaria, 245–248
Kaminskyj, Susan G. W., 125 Mapping experiments, 158
KCA, 183–184 Marcott, Curtis, 105
Kidney biopsy, 114, 115 Materials. See Biomaterials
Kidney disease, 111 Materials and methods, 10–25
Kim, Hyunmin, 342 Matrigel, 84–86
Klarite substrate, 148 Mattson, Eric, 29
Krafft, Christoph, 225 Maximum entropy method (MEM),
Krishnamachari, Vishnu, 342 329
MCR, 183, 278
MCT detector, 105
L L MD, 174–177, 181
Laminin, 83 MD classifier, 181
Laser, 269–270 Medical applications. See Raman
LCTF, 159–160, 271, 273, 275 microscopy for biomedical
LDA, 184–186 applications
Least squares (LS), 169, 278 MEM, 329
Least-squares analysis (LSA), 184 Meninges, 231
Leave-one-out testing, 251 Meningioma, 231–233
Liao, C. L., 152 Mercury cadmium telluride (MCT)
Light absorption, 333 detector, 105
Light scattering, 333 Methylene bridge, 67
Lim, Ryan, 342 Microscope, 270