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10.5 EXTRACTION OF GENES AND SCREENING OF DRUGS 255

We collected all the necessary information for our ten selected genes along with their three-
dimensional structures from the protein data bank (PDB). The PDB contains the protein structural
information obtained from XRD crystallography, nuclear magnetic resonance spectroscopy, and the-
oretical modeling [46]. The lists of all the reported drugs were downloaded from the drug bank database
for the ten target proteins. Table 10.3 shows the list of drugs for each protein. Drug bank 1.0, released in
2006, was updated to Drug bank 4.0 in 2014 [48].

Table 10.3 Most Responsible Genes, Their Encoding Proteins, and Targeted Drugs for
Alzheimer’s Disease
Gene Name Encoding Protein Drugs Drug Bank ID
SNCA Alpha-synuclein Copper DB09130
Resveratrol DB02709
PRNP Major prion protein Tetracycline DB00759
PSEN1 Presenilin-1 Absent Absent
PPP3CA Thereonine protein Myristic Acid DB08231
Tetracycline DB00759
JUN Transcription factor AP-1 Arsenic trioxide DB01169
Irbesartan DB01029
Pseudoephedrine DB00852
Vinblastine DB00570
GSK3B Glycogen synthase Alsterpaullone DB04014
kinase-3 beta I-5 DB01793
Indirubin-3’-Monoxime DB02052
Lithium DB01356
Phosphoaminophosphonic DB04395
Acid-Adenylate Ester
Staurosporine DB02010
CDK5 Cyclin-dependent-like Alsterpaullone DB04014
kinase 5 Flavopiridol DB03496
Hymenialdisine DB02950
Indirubin-3’-Monoxime DB02052
Olomoucine DB02116
SU9516 DB03428
PSEN2 Presenilin-2 Absent Absent
APBA2 Amyloid β A4 protein Absent Absent
PTGS2 Prostaglandin G/H synthase 2 Acetaminophen DB00316
Aldesleukin DB00041
Bromfenac DB00963
Carprofen DB00821
Dapsone DB00250
Desmopressin DB00035
Magnesium salicylate DB01397
Oxaprozin DB00991
Resveratrol DB02709
Gene name, encoding protein, name of drug, and drug bank ID are given in the table using Uniprot [47] and the drug bank
database [48].