Page 482 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

458 Index
α-alkyl-α-hydroxycarboxylic acids 261 – regeneration, whole-cell biocatalysts
aluminum catalyzed racemization 434 114–115
Amberlite XAD-7 207 artificial cascades 257
amberlite-based racemization 438 aryl olefins, biocatalytic asymmetric
amidase dihydroxylation 49
– activity and stability, nitrile effect 289–293 arylacetonitrilases 277–278
– cascade substrate selectivity 304–308 L-arylalanines 443
– structure and mechanism 304 asymmetric dihydroxylation, aryl olefins 49
amidase-and nitrile hydratases-catalyzed asymmetric reductive amination 66–69
reaction 286 ATP-binding cassette (ABC) protein 235
amide formation 305 auxiliary agents, enzymes as 317–325
amination 67–69 azetidine-2-carbonitriles 251
– of alcohols 70, 71 azobisisobutyronitrile (AIBN) 435
amine-catalyzed racemization 438
amines 434–436 b
– kinetic resolution of 213, 214
bacterial methyltransferases 404
amino acid esters racemization 187
bacterial nitrilases 274
amino acid oxidase (AAO) 233
Baeyer–Villiger monooxygenase (BVMO)
amino acid precursors 331–334 27, 45, 46, 52, 53, 56, 57
N-protected-amino acid thioesters 191–192 Baeyer–Villiger oxidation 45, 59, 60
α-amino acids 162, 170–171, 182, 298 β-alanine 172
α-D-amino acids 163 β-alanine synthase. See N-carbamoyl-β-alanine
β-amino acids 297–309 amidohydrolase (NCβAA)
– production 161–174 β-amino acids
δ-amino acids 170–171 – biocatalytic preparation of enantiopure
L-amino acids 436 299–301
α-amino esters 436, 437 – chemical methods for generating 298–299
α-amino-α-caprolactam racemase 257 – stereoselective synthesis of 297–309
aminoacylase 299–300 base-catalyzed enolization 183
– cross linked enzyme aggregate (CLEA) of base-catalyzed racemization 180, 183–185,
211 189
amino-and hydroxynitriles 303 β-carbamoylase 166, 173, 174
2-amino-1,3,4-butanetriol 207 benzaldehyde dehydrogenase (BZDH) 52
aminocyclitol synthesis 340–351 benzofurane 441
2-aminoethylphosphonate (2-AEP) 161 3-(oxiran-2yl)benzoic acid 48
β-aminoisobutyric acid 161–162, 166 benzonitrile 252, 253, 263, 285, 289
2-aminonitriles 254 benzyl alcohol dehydrogenase (BADH) 52
β-aminonitriles 254, 306 N-benzyloxycarbonyl (Cbz)-protected
aminotransferases 66 aminoaldehyde derivatives 340–341, 349,
amminolysis, of N-Boc-aminothioesters 193 350
ammonolysis, of phenylglycine methyl ester biaryl-substituted alcohol 447
186 Bifidobacterium longum UDP-sugar
amperometric transketolase assay 323–325 pyrophosphorylase (BLUSP) enzyme 148
aromatase CYP19A1 catalysis 94, 96 biocatalyst engineering 153
aromatic nitrilases 278 biomimetic reductive amination process 203
artemisinin-based combination therapies (+)-biotinamidohexanoic acid hydrazide 142
(ACTs) 120 biphasic MTBE/buffer system 190
artificial cascade reactions, cytochrome P450 blood-tolerant laccase 9
enzymes N-Boc-amino acid thioesters hydrolysis 193
– cofactor regenerating enzymes 108–113 N-Boc-aminothioesters 193
– multi-enzyme cascades, in vivo 120–124 N-Boc-phenylglycine thioesters 191
– multi-enzyme cascades, isolated enzymes bovine adrenodoxin (Adx) 114–115
116–120 bovine serum albumin (BSA), 319–325