Page 486 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

462 Index
Leloir pathway 363, 366, 367, 372, 389 – cofactors 400–403
Leloir-glycosyltransferases 134, 135 – higher homologs and derivatives 403–406
Leloir-path sialyltransfer enzymes 368 – radical-SAMenzymes 395–396
lignin – substrates 396–400
– combustion 3 N-methyltransferases (NMTs) 414, 417
– degradation 3, 5 Michaelis–Menten kinetics, PFR type reactor
lignin peroxidases (LiPs) 3, 5, 11 200–201
lignin polymer 5 microbial transketolase 315
ligninolytic enzymatic consortium 1, 3–6 microreactor technology 199, 203
ligninolytic high-redox potential laccases, mining genomes for nitrilases 271–279
directed evolution of 8–11 mitochondrial CYP11B2 93
ligninolytic oxidoreductases 1–17 mitochondrial cytochrome CYP11A1 92, 93,
ligninolytic peroxidases 11 95
lignocellulosic materials 6 Mn peroxidases 11
Li-HPA 325, 326, 330 molecular oxygen fixation, monooxygenases
linear cascade reactions 69–82 44
lipase-catalyzed acylation 212, 213 monooxygenase-catalyzed redox cascade
lipase-catalyzed hydrolytic reactions 252 biotransformations 43–61
lipase-catalyzed kinetic resolution 212 monooxygenated metabolites 97
lipase-catalyzed reactions 204 5-monosubstituted hydantoins 162, 163
lipase-nitrile hydratase-amidase 263–264 5-and 6-monosubstituted dihydrouracils
lipases 207, 211, 231, 299–300, 450 (DHUs) 162, 164, 165
low-redox potential laccases, directed multienzyme system
evolution of 7 – biocatalyst options 233–237
– classification 233, 234
m – compartmentalization 237
mediator-coupled enzyme systems 35–37 – process control 244
medium-redox potential laccases, directed – process development 239–244
evolution of 7–8 – process engineering 241
membrane bioreactors (MBRs) 201, 208, 210 – process modeling 241–244
metabolic diversification 385 – transport limitations 235–237
metabolic engineering 16, 385, 409 multistep cascade reactions 87–88
metal catalysis 445–449 multistep oxidations catalyzation
metal catalysts 283, 430, 432, 433, 436, 445 – multiple P450 102–108
metal-catalyzed hydrogenation 446 – single P450 92–101
metal-catalyzed racemization 431, 433 mutagenesis, site-directed 134, 135
metal-catalyzed transformation 449 mutagenic organized recombination process
metallo-enzymes 302 by homologous in vivo grouping
metathesis 449 (MORPHING) 14–16
α-methionine 172 Myceliophthora thermophila laccase (MtL) 7,
methyl dodecanoate 72 8, 16
methylation 393, 394, 398, 400
methylene groups oxidation 49, 50, 119 n
methylenedioxo motif 416 NAD(H)-dependent dehydrogenases
3-methylthietan-2-one hydrolysis 207 317–319
O-methyltransferase (OMT) 410, 414, 416, NADH cofactor regeneration 28
417 NAD(P)H oxidases (NOXs) 32–34
methyltransferases (MTs) 393–417 NADH regeneration 30, 37
– bacterial 404 NADH-dependent dehydrogenase 318
methyltransferases, S-adenosyl-L-methionine NAD(P)H-dependent dehydrogenases 23
(SAM) dependent (S)-naproxen 208, 210
– acting on small molecules 398–400 natural cascades 250–257
– cascade applications 410–415 neo-sialoconjugates synthesis 378–388
– cofactor (re)generation 406–410 neuraminic acid 370