Page 483 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

Index 459
Brevibacterium sp. K1309 (Bs-NOX) enzyme cis-dihydroxylation of benzonitrile 263
33–34 CLEA. See cross-linked enzyme aggregate
Burkholderia cepacia lipase 219 CMP-sialic acid synthetase (CSS) 372,
BVMO. See Baeyer–Villiger monooxygenase 374–377, 389
coenzyme A (CoA) 161
c coenzyme regeneration enzyme (CRE) 46,
CaLB. See Candida antarctica lipase B 108
calcium channel blocker 102 cofactor recycling 44–46
camphor oxidation 113 Co-(III) nitrile hydratases 304
Candida antarctica lipase B (CaLB) 212, 214, combinatorial libraries enhanced by
220, 300, 435 recombination in yeast (CLERY ) 16
Candida rugosa lipase (CrL) 186, 207, 209, compartmentalization 237, 240
210, 213 continuous ideally stirred tank reactor
capravirine metabolism 96–98 (CISTR) 200, 201
ε-caprolactone (ε-CL) 445 continuous stirred ultrafiltration
carbaldehyde, amination of 77 (UF)-membrane bioreactors (CSMRs) 284,
N-carbamoyl-α-methyl-β-alanine 167 285, 287, 289, 290, 292
L-N-α-carbamoylase and D-N-α-carbamoylase continuous-flow enzyme reactors 206
167, 169 continuous-flow kinetic resolution 212, 213,
N-carbamoyl-β-alanine amidohydrolase 220
(NCβAA) 162, 163, 166–173 continuous-flow systems
N-carbamoyl-β-amino acids 163 – homogeneous vs. heterogeneous 199–200
carbohydrate-active enzyme (CAZy) 134, 377 – micro vs. mini reactors 202
carbohydrates 351–355 – reactions in 199–204
carbon–carbon bond formation 80, 259, 319, continuous-flow/stopped-flow (SF) methods
322, 326, 355, 368, 371, 398, 438, 439, 446 203
carbonyl amination 75–78 continuous-stirred tank reactors (CSTRs)
3-carboxymuconate 53 210, 220, 237, 238
catalytic cycle, P450 monooxygenases 89–90 convergent synthesis 138, 151–153
catechol-O-methyltransferase (COMT) 398, Coprinopsis cinerea peroxidase (CIP) 12
400 creatinine analysis 203
CAZy. See carbohydrate-active enzyme cross-linked enzyme aggregate (CLEA) 211,
cell-free systems (in vitro) 108–113 252
cellobiose dehydrogenase (CDH) 5 cyanide hydratases 273–275
chemocatalysis 428, 439–442 – properties and applications 277–279
chemo-enzymatic cascade reactions 56–60, cyanide-transforming enzymes 279
133–153, 325–326 (±)-α-cyano-α-fluoro-α-phenylacetic acid
chemoenzymatic multistep one-pot processes (CFPA) 253
427–453 1-cyano-2-methoxymethyl ferrocene 255
– chemo process 443–452 cyanopyridine 256, 259
– isomerization and derivatization 429–438 cyclic β-amino acid 438
– isomerization of substrate 428 cyclic malonic acid monoester derivative 449
– substrate synthesis and derivatization cycloalkanones synthesis 117
438–452 trans-1,2-cyclohexanediol acetylation 220
chemoenzymatic synthesis 323, 340, 379 cyclohexanol oxidation 48
′
chiral amines 65 cytidine 5 -monophosphate sialic acid
chiroptical measurements 191–192 synthetase (CSS) 364
1-chloro-2-acetoxy-3-(1-naphthyloxy)-propane cytidine triphosphate (CTP) 372
222 cytochrome P450 enzymes, artificial cascade
chlorobenzene dioxygenase (CBDO) 263 reactions
cholesterol oxidation 93 – cofactor regenerating enzymes 108–113
ciliatine 161 – multi-enzyme cascades, in vivo 120–124
cinnamyl alcohol 54 – multi-enzyme cascades, isolated enzymes
cis-dihydrodiols 262 116–120