Page 484 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

460 Index
cytochrome P450 enzymes, artificial cascade e
reactions (contd.) ebastine metabolism 103–104
enantioselective acylation, of prochiral diols
– regeneration, whole-cell biocatalysts
212
114–115
enoate reductase 53, 57
cytochrome P450 monooxygenases 87–125
ent-kaurene oxidation 101
cytosine 405
enzyme engineering 60, 265, 404
enzyme-mediator systems 35–37
d D-erythrose-4-phosphate (D-E4P) 318
N-dealkylations 102, 104 ester hydrolysis 436–437, 449
dehydrogenase-catalyzed oxidation reactions ethyl carbamate oxidation 100
23
demethylation, of lanosterol 97 f
N-demethylations 106 D-fagomine 349
deoxycorticosterone, oxidation 94 farnesyl pyrophosphate (FPP) 120
deoxysugars 340 FDH. See formate dehydrogenase
deracemization 66–67 Fe-(III) nitrile hydratases 304
– of profen thioesters 189 ferredoxin hydrogenase 29
– of racemic amines 78–79 flavin mononucleotide (FMN) cofactor 28
3,5-dichlorosalicylaldehyde-catalyzed flow-through approach, advantages 199
racemization 437 fluidized-bed reactors 201
dihydropyrimidinase 163–166 fluorescent intensity (FLINT) 318
5-dihydrouracils 163 fluorogenic transketolase assay 319–321
dihydrouracils (DHUs), 5-and 5-or 9-fluorophore-labeled sialoconjugates
6-monosubstituted 162, 164, 165 381
dihydroxyacetone (DHA) 330, 346–351, 353, fluoropyruvate 381
355 formate dehydrogenase (FDH) 24–26,
dihydroxyacetone phosphate (DHAP) 317, 111–112
320, 322, 340, 341, 343–345, 347 Friedel-Crafts-type alkylation 452
dinitriles 253, 279 D-fructose 6-phosphate (D-F6P) 318
directed molecular evolution 1–3 D-fructose 429, 430
disaccharides 370–371 fructose-6-phosphate aldolase (FSA) 330,
2,6-disubstituted piperidines 75 342, 348–350, 352, 355
DKR. See dynamic kinetic resolution L-fuculose-1-phosphate aldolase (FucA)
DL-Ac-Phe, kinetic resolution of 211 341–344, 347, 348
DNA fusion engineering 27
– methylation 393, 394, 400
– methyltransferases 398, 404, 407 g
dodecanoic acid methyl ester 55 γ-amino-n-butyric acid (GABA) 161
dopamine methylation 400 ganglioside 144
dTDP-activated deoxysugar synthesis 139 geranylgeranyl pyrophosphate (GGPP) 122
dTDP-deoxy sugars synthesis 141 glucose dehydrogenase (GDH) 24–26
dTDP-2-deoxy-arabino-hexose 139 glucose-6-phosphate dehydrogenase
dTDP-deoxyhexoses 139 (G-6P-DH) 29, 108–110
dTDPdeoxysugars 147 – regeneration of NADPH by 30
dTDP-2,6-dideoxyhexoses synthesis 140 glycan microarray technology 388
dynamic kinetic resolution (DKR) 179–194, glycan-binding proteins 388
210, 212, 428–438 glycans 133, 137, 144, 148–151
– of amino acid esters 186 D-glyceraldehyde 3-phosphate (D-G3P) 317,
– of aminoesters 187 318
– applications of 183–193 D-glycerol 3-phosphate 317
–of N-Boc-phenylglycine thioesters 191 glycerol-3-phosphate dehydrogenase (GPDH)
– of oxoesters 185–188 318
– of thioesters 188–193 glycoconjugates 363