Page 487 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

Index 463
neuraminic acid aldolase (NeuA) 368–371, oxoesters, dynamic kinetic resolution of
381, 383, 385 185–188
neuraminic acid synthase 371–372 oxy-functionalized heteroaromatic compounds
nicotinic acid 254 452
nitrilase-amidase 258–259 oxygenase-nitrilase 262–263
nitrilase-catalyzed transformations 272 oxynitrilase. See hydroxynitrile lyases (HnLs)
– hypothetical mechanism of 273
nitrilases 258, 271–272 p
– analysis of specific regions 276 packed bed reactor (PBR) 208, 218–220, 222,
– bacterial 274 237, 238
– enzyme mutants analysis 276–277 – in hydrolase-catalyzed acylation 213
– in fungi 274–275
– hydrolysis in 208
– mining genomes for 271–279
Pasteurella multocida hyaluronan synthase
– in plants 275
(PmHAS) 144–145
– properties and applications 277–279
pathway engineering 121, 122, 414
– sequence clustering 275–276
peptide glycosylation 151
– sequences diversity 272–274
peptidomimetics 297–298
– structure and mechanism 301
peroxidases and peroxygenases, directed
– structure-function relationships in
evolution of 11–15
275–277
– substrate selectivity 302 peroxygenases, unspecific 3, 15, 16
nitrile containing compounds 249, 250, 264 phenol red 326–329
nitrile converting biocatalysts 300–301 phenylacetonitrile 257
nitrile converting enzymes 249–265 phenylglycine methyl ester, ammonolysis of
nitrile hydratase-amidase 250–255, 257–258 186
nitrile hydratases (NHases) 250, 251, 302 phenylpropanoids 410
– activity and stability 287–289 phosphatase-catalyzed reaction 439
– cascade substrate selectivity 304–308 phosphite dehydrogenase
– structure and mechanism 303 ′ (PTDH) 26–27 ′
nitrile hydratases-amidase bi-enzymatic 5 -phosphoadenosine 3 -phosphosulfate
cascade system 284–287 (PAPS) 146
nitrile hydrolysis enzymes 301 phosphoenolpyruvate (PEP) 364
Ni-nitrilotriacetic acid (Ni-NTA) complex 207 phosphoglucomutase (PGM) 139
non-nucleoside reverse transcriptase inhibitor physiological cascade reactions, P450
96 91–108
nonstereoselective enzymatic processes 204 α-pinene 114, 115
nucleoside diphosphate (NDP) 146 L-pipecolic acid 442
nucleotide activation of sialic acids 372–373 plug-flow reactor (PFR) 200, 201
nucleotide sugars 135, 139–141, 146–148 PM1 laccase (PM1L) 8, 10, 11, 16
polyacrylonitriles (PANs) 255
o polyhydroxylated compounds 351–355
omeprazole metabolism 102–103 poly-LacNAc oligomers 151
one-pot reduction–oxidation–hydrolysis poly-LacNAc structures
54 – convergent synthesis of 152
one-pot synthesis 134, 138, 146–151, 258, – one-pot synthesis of 143
379–385 polymerase chain reaction (PCR) 2, 26
– of poly-LacNAc structures 143 polyphenol oxidase 321–322
opium alkaloids 415 polyphenoloxidase (PPO) biosensor 322–324
organocatalysis 231, 440, 449–452 poly(ethylene glycol) (PEG)-polymer 149
organocatalytic dehydration 440 poly(ε-caprolactone)-type polyester 446
organonitriles detoxification 283 porcine pancreas lipase (PPL) 213
orthogonal cascades 44 post-synthetic diversification 386–387
oxazinone hydrolysis 438 potential reactor configurations 238
oxidoreductase-catalyzed reactions 442 process engineering 241