Page 485 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

Index 461
– synthesis 133–153 hydroxynitrile lyase-nitrilase-amidase 261
glycolaldehyde (GO) 349, 352–354, 356 hydroxynitrile lyase-nitrile hydratase
glycomics 133 261–262
glycosidases 136–137 hydroxynitrile lyases (HnLs) 259–261
glycosyl fluorides 137 hydroxypyruvate (HPA) 315, 316
glycosylation 133
glycosylazides 137 i
glycosyltransferases (GTs) 134–135, 139, (S)-ibuprofen 208, 213
147, 149, 150, 377, 378 iminocyclitol synthesis 340–351
glycosynthases 136–137 immobilization, enzyme 220–222
guanosine monophosphate (GMP) 148 immobilization techniques evolution
199–200
h
in situ enzymatic recycling, NAD(P)(H)
Heck reaction 448
cofactors 23–38
Henry reaction 350, 438, 439
in situ nitrile hydratase/amidase enzymatic
heparin oligosaccharide 144 system 283
heparosan oligosaccharides 144 in situ product removal (ISPR) technique 30,
(R)-heptanol and heptanone synthesis 118 31, 241
high-redox potential laccases (HRPLs) 3, 5, 6 in situ regeneration of oxidized NAD(P)+
– directed evolution of ligninolytic 8–11 cofactors 31–37
high-throughput screening (HTS) 2, 8, 10, in situ regeneration of reduced NAD(P)H
15, 316, 318, 321, 326, 376 cofactors 24–31
hollow fiber membrane bioreactor 208, 210 in vivo assembly of mutant libraries (IvAM)
β-homoalanine 161 14, 16
Horner–Wadsworth–Emmons olefination in vivo metabolism 329
reaction 439 in vivo multistep biocatalysis 51–56
horse liver alcohol dehydrogenase (HLADH) in vivo overlap extension (IVOE) 14, 16
204 induced resistance defense mechanism 161
horseradish peroxidase (HRP) 12 inorganic phosphite oxidation 26
hyaluronan oligosaccharides 144 ion-exchange-polymer-catalyzed epimerization
hydantoinase process 162–164
59
hydantoins, 5-monosubstituted 162, 163
L-isoaspartate 398
hydrogenase 27–29
hydrolase-catalyzed acylation 211, 213
k
hydrolase-catalyzed continuous-flow
ketones 67, 260
techniques 214
– oxidation 50
hydrolase-filled continuous-flow reactors
215–217 – reduction 202, 448
hydrolases 203, 207, 211 (S)-ketoprofen 208
hydrolytic enzymes 203, 410 kinetic resolutions (KRs) 66–67, 179, 208,
hydrolytic processes, in continuous-flow 210–220, 222, 299
system 211
hydrolytic reactions 202, 208 l
ω-hydroxy acids 50 laccase-catalyzed biotransformation 450, 452
β-hydroxy nitriles 251 laccase-mediator systems 7
2-hydroxy-γ-butyrolactone (HBL) 208 laccases
hydroxyacetone (HA) 349–354, 356 – blood-tolerant 9
hydroxyaldehyde 321 – directed evolution of 6–11
hydroxybutanone (HB) 349, 352–354 – PM1 8, 10, 11, 16
(S)-2-hydroxycarboxylic amides 262 β-lactam carbonitriles 251
hydroxylation reaction, P450 monooxygenases β-lactam-recognizing enzymes (BLREs) 307
88, 89 lactate dehydrogenase (LDH) 28, 31–32
5-hydroxymethylcytosine (hmC) 404 layered double hydroxides (LDHs) 322
Ⓡ
hydroxynitrile lyase-nitrilase 259–261 Lecitase Ultra 208