Page 488 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

464 Index
prochiral diols, enantioselective acylation of s
212 Saccharomyces cerevisiae biomolecular tool box
profen thioesters deracemization 189 15–16
progesterone oxidation 116 selenium-based cofactor analog 404
promiscuity 169 self-supported chiral titanium cluster (SCTC)
protein engineering 2, 24, 37, 65, 87, 124, catalyst 203
135, 137, 144, 180, 240, 241, 244, 245, 346, sialoconjugate arrays applications 388
356, 384, 389 sialoconjugate diversity 361–389
protein methylation 400 sialoconjugate libraries 363–378
protein molecular models 350 sialoconjugates, 5-or 9-fluorophore-labeled
protein processing, maturation and exocytosis 381
13 sialyl acceptor 378–379
proteins arginine-N-methyltransferase sialylated oligosaccharide 361, 362, 383
(PRMT) 398 sialylation 361, 383
proteomics 203–204 sialyltransfer reactions 382
Pseudomonas cepacia lipase (PcL) 207 sialytransferase (SiaT) 364, 377–379, 381,
Pseudomonas fluorescens lipase (PfL) 212 383
putative racemization mechanism 190 Sinorhizobium meliloti (SmelDhp) 163–165
putrescine-NMT 414–415 sitagliptin 298
Pycnoporus cinnabarinus laccase (PcL) 8, 10, staggered extension process (StEP) 14, 16
11, 16 stereoselective acylations 211–220
pyrene oxidations 97, 99 stereoselective carboligation 330
pyridinedicarbonitriles 253 stereoselective enzyme reactions 204–222
pyridoxal phosphate (PLP) 66, 185, 186 stereoselective hydrolase-catalyzed process
– catalyzed racemization 436 199–222
′
pyridoxamine-5 -phosphate (PMP) 66 stereoselective hydrolytic reactions
pyrolytic graphite (PG) particles 28 207–211
stereoselective synthesis
–of β-amino acids 297–309
r –of 14(S),15(R)-epoxyeicosatrienoic acid
racemization, amine-catalyzed 438
110
reaction engineering 181, 194, 453
– of epoxyhexane 111
reactor configurations, potential 238
steroid 11β-hydroxylase. See mitochondrial
recombinant DNA (rDNA) technology 240
CYP11B2
redox and redox-neutral cascade reactions
Strecker reaction 203, 254
70–75
styrene monooxygenase (SMO) 46, 47
redox chromophore 325–326
β-substituted β-adrenergic agents 297
redox systems, P450 monooxygenases 89–90 substrate binding model 373–376
redox toolbox concept 56 substrate engineering 181, 183, 194
redox-balanced biocatalytic system 45
substrate-binding interactions 375
regio-and stereoselective dihydroxymyristic
substrate-coupled approach 29
acid synthesis 109
subtilisin-catalyzed process 214
L-rhamnulose-1-phosphate aldolase (RhuA)
sucrose synthase (SuSy) 146
341, 342, 344–349
Suzuki reaction 446–448
rhodium catalyzed racemization 431
Rhodococcus erythropolis A4 252–254, 258,
264 t
Rhodococcus erythropolis AJ270 251, 253 tamoxifen metabolism 104, 106, 107
Rhodococcus rhodochrous PA-34 whole cells taurine 161
255 taxol 120, 122
(R)-rhododendrol 448 tetrasaccharide synthesis 382
D-ribose 5-phosphate (D-R5P) 317, 330 tetrazolium red 325
RNA methylation 400 thermophilic alcohol dehydrogenase (TADH)
ruthenium catalyzed racemization 432, 433 206