Page 172 - Computational Modeling in Biomedical Engineering and Medical Physics
P. 172

Bioimpedance methods  161


                   without loss of accuracy, the AC model may be replaced with a simpler DC model. This
                   may be explained by the irrotationality of the electric field and the apparent disparity
                   between the operating frequency of the ECM and the hemodynamic of the time scale.
                      A key problem of the electromechanic coupling is the blood electrical conductivity.
                   This is solved here with an equivalent quantity, calculated out of analytical expressions
                   using averaging methods. However, some electrophysiology effects are not evidenced
                   when embracing the numerical model, for example, the nonlinear change in the blood
                   electrical conductivity that happens for increasing and decreasing the flow rates. Even so,
                   the sensitivity of the solution to blood flow pulsations is evidently outlined.
                      The ECM impedance and its derivative with respect to time found by numerical
                   modelization fit fairly well with the experimental results. Significant cardio-hemodynamic
                   indices, consistent with experimental findings, are evidenced by the numerical results.
                   Several cardiovascular indices of importance in medical diagnosis become thus mathemati-
                   cally tractable, for example: the start of blood ejection by the left ventricle, the systolic
                   major upward deflection, the aortic valve closure, the diastolic upward deflection, the left-
                   ventricular ejection time, and dZ/dt max .

                   5.6 The ECM brachial bioimpedance

                   A localized version of EVM model for the arm, called transbrachial electrical bioimpe-
                   dance velocimetry (TBEVM), was proposed to compute SV (Henry et al., 2012). Later,
                   the (BCVI) introduced by Dobre et al. (2017) and Morega et al. (2018) was modeled to
                   elicit brachial cardiovascular indices at the arm level, which is the traditional place for
                   blood pressure measurement (Fig. 5.12).
                      This particular location is favored by the presence and accessibility of the brachial
                   artery, close to the aortic arch, and relatively close to the surface of the arm. It may be
                   inferred that, although may be not all hemodynamic indices are available as compared
                   to the ECM, BCVI is a relevant, useful, and easily accessible cardiovascular monitoring
                   technique, complemented by blood pressure monitoring.

















                   Figure 5.12 The BCVI implementation.
   167   168   169   170   171   172   173   174   175   176   177