Page 191 - Modern Derivatization Methods for Separation Sciences

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ceramide (GlcCer), lactosyl ceramide (LacCer) and globotriaosyl ceramide (GbOse3Cer) were clearly
separated and the detection limit was 50 pmol. This method was applicable to the rapid urinary
diagnosis of Fabry's disease, which is a inborn error of glycoshpingolipid metabolism caused by
lysosomal a-galactosidase A deficiency. The typical chromatograms obtained from a normal and a
patient sample were shown in Fig. 2.3.1.

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