Page 119 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions
P. 119
5.2 Physiological Cascade Reactions Involving P450s 95
O O
O
20
17
CYP 17α-hydroxylase OH CYP 17,20-lyase H 17
H H
H H
H H H H
O O
O O
Progesterone 17α-Hydroxyprogesterone OH Androstenedione
(a)
O O
O
20
17
CYP 17α-hydroxylase OH CYP17,20-lyase 17
H H H
H H
H H H H O
HO HO HO
Pregnenolone 17α-Hydroxypregnenolone OH Dihydroepiandrosterone
(b)
Scheme 5.6 Hydroxylase and lyase activities of CYP17A1 in multistep progesterone (a) and prenenolone (b) conversion.
