Page 129 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions
P. 129
5.2 Physiological Cascade Reactions Involving P450s 105
O O NO 2 O O NO 2
CYPs 2C9/1A2/2C19 6
HO
OH OH
O O
(R)-Acenocoumarol 6-Hydroxy-(R)-acenocoumarol
OH
HO O O NO 2 8 O O NO 2
7
CYPs 2C9/2C19
OH OH
O O
7-Hydroxy-(R)-acenocoumarol 8-Hydroxy-(R)-acenocoumarol
Scheme 5.16 Metabolism of acenocoumarol by different hydroxylations.
