Page 81 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

3.1 Introduction 57

Model reaction
OH O O O
LK-ADH XenB CHMO Acineto O
NADP + NADPH NADPH NADP + NADPH NADP +

Substrate scope:
OH OH OH
OH

R 1 = H
Me
R 1
Desymmetrization Kinetic resolution Regiodivergent biotransformation
O O O O O O O O
O O O O
+ +

R 1 R 1
Scheme 3.17 Artificial metabolic pathway composed by an alcohol dehydrogenase (LK-ADH), an enoate reductase (XenB), and a
Baeyer–Villiger monooxygenase (BVMO Acineto ): different substrate types that have been successfully converted to chiral products
via this pathway.