Page 96 - Chiral Separation Techniques

72 3 Combinatorial Approaches to Recognition of Chirality: Preparation …

Table 3-3. Enantioseparation of 2-methylnaphthoyl-N,N-diethylamide and naproxene methyl ester
using CSPs 1-11.

CSP k α k α
1 1
1 5.67 1.10 3.19 1.33
2 a 6.48 1.08 3.64 1.33
3 10.43 1.10 3.16 1.00
4 a 9.08 1.07 2.54 1.00
5 6.64 1.15 1.81 1.00
6 7.60 1.10 2.18 1.00
7 5.28 1.12 1.45 1.00
8 4.95 1.03 5.30 1.29
9 7.77 1.11 1.87 1.00
10 4.81 1.13 1.35 1.00
11 3.15 2.22 8.06 1.84
a Commercial CSPs 2 and 4 from Regis Technologies, Inc. (Morton Grove, IL) have selectors close to those of CSPs
1 and 3, respectively.
–1
Conditions: mobile phase 10 % 2-propanol in hexane, column 250 × 4.6 mm i.d., flow rate 2 mL min , UV detec-
tion at 254 nm.
viable alternative to the more traditional approaches and opened the access to
libraries of chiral separation media.