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Fundamentals of Experimental Design  429


           Step 0: Preparation
             Establish analysis matrix for the problem. The analysis matrix is a matrix
           that has not only all columns for factors but also the columns for all
           interactions. The interaction columns are obtained by multiplying the
           corresponding columns of factors involved. For example, in a 2 exper-
                                                                     2
           iment, the analysis matrix is as follows, where the AB column is gen-
           erated by multiplying the A and B columns:


           Run number    A   B       AB
                                     *
                1       1    1   ( 1) ( 1)    1
                2       1    1   ( 1) * ( 1)    1
                3       1    1   ( 1) * ( 1)    1
                                     *
                4       1    1   ( 1) ( 1)    1
             Attach experimental data on the analysis matrix. In Table 12.8 we use the
           data in Example 12.5 to illustrate this attachment.

           Step 1: Compute contrasts. The vector of column coefficients multiply-
           ing the vector of totals computes a contrast. In Table 12.8, the column
           coefficients for A (second column) is ( 1,  1,  1,  1) and the vector of
           the total is [(1), a, b, ab]   (64.4, 96.1, 59.7, 161.1). Therefore

           Contrast A    (1)   a   b   ab   64.4   96.1   59.7
                         161.1   133.1

           Similarly

           Contrast B    (1)   a   b   ab   64.4   96.1   59.7   161.1   60.3
           Contrast AB   (1)   a   b   ab   64.4   96.1   59.7   161.1   69.7

           Contrasts are the basis for many subsequent calculations.

           Step 2: Compute effects. Effects include both main effects and interac-
           tion effects. All effects are computed by the following formula:


           TABLE 12.8 Analysis Matrix and Data for Example 11.5
             Run       Effects          Responses
           number   A    B   AB     1    2     3    4      Total
              1      1   1    1   18.2  18.9  12.9  14.4  (1)   64.4
              2      1   1    1   27.2  24.0  22.4  22.5  a   96.1
              3      1   1    1   15.9  14.5  15.1  14.2  b   59.7
              4      1   1     1  41.0  43.9  36.3  39.9  ab   161.1
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