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Fundamentals of Experimental Design  431

                                   2   k    n           2
                                                      y...
                                                2
                            SS T   
 
 
       y ijk                  (12.10)
                                  i   1 j   1 k   1  N 
 n
           where y ijk is actually each individual response and y... is the sum of all
           individual responses.
             In Example 12.5

           SS T   18.2   18.9    …    39.9 2
                             2
                      2
                    (18.2   18.9    …    39.9) 2
                                                1709.83
                               16
           SS E can be calculated by

                             SS E   SS T   SS A   SS B   SS AB
           In Example 12.5
           SS E   SS T   SS A   SS B   SS AB   1709.83   1107.22   227.25
                   303.6   71.72

           Step 4: Complete ANOVA table. The ANOVA table computation is the
           same as that of general factorial design. MINITAB or other statistical
           software can calculate the ANOVA table conveniently. In the example
           above, the ANOVA table computed by MINITAB is as follows:

             Analysis of Variance for y, using Adjusted SS for Tests
             Source   DF    Seq SS    Adj SS     Adj MS       F       P
             A         1   1107.23   1107.23    1107.23  185.25   0.000
             B         1    227.26    227.26     227.26   38.02   0.000
             A*B       1    303.63    303.63     303.63   50.80   0.000
             Error    12     71.72     71.72       5.98
             Total    15   1709.83

           Clearly, both main effects, A and B, as well as interaction AB, are all
           statistically significant.

           Step 5: Plot main-effects and interaction charts for all significant effects.
           For any main effect, such as main-effect  A, the main-effects plot is
           actually the plot of y A   and y A   versus the levels of A. The interaction




           chart is plotted by charting all combinations of y A   B  , y A   B  , y A   B   and


           y A   B  . For Example 12.5, the main-effects plot and interaction chart
           are shown in Figs. 12.5 and 12.6, respectively.
           Step 6: Establish a mathematical model. We can establish a regression
           model for the data. Here are the rules:
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