Page 353 - Advances in Biomechanics and Tissue Regeneration

113]
[120]
[119]
[121]
[116]
[114]
[111]
[112,
laminin
to
not
synthesis
but
IV
type
"Protein
pathways
collagen
receptor.
"Elongation
signaling
and
pathway
pathway
pathway
pathway
fibronectin
1
type
synthesis
Akt
stretch)
stretch)
signaling
signaling
II
signaling
signaling
and
angiotensin
β1-integrins
β1-integrins
release
to
(cyclic
#PGE2
(static
ERK1/2
"DNA
adhesion
ERK
ERK
Akt
Akt
Il-1
influx
protease
protease
#PKA
"Proliferation
"Proliferation
Antiapoptotic
Antiapoptotic
by
by
by
by
of
of
of
of
Loading
of
Substrate
Activation
Activation
Activation
Activation
Activation
Regulated
Regulated
#K10
Regulated
Regulated
"Calcium
#cAMP
uPA
uPA
"K6
Tension 352 Reference response Mechanotransduced [110] "IL-1α antagonist "IL-1R media by mediated cells endothelial vascular human in "E-selectin KCs stimulated mechanically by conditioned endothelium vascular Activate 17. SKIN MECHANOBIOLOGY AND BIOMECHANICS: FROM HOMEOSTASIS TO WOUND HEALING [124] stress to perpendicular Orientation area Reduced protease MMP-9 "
#
"
"
to
Subjected Cell KCs hNFKCs HaCaT NHK HaCaT NHK HaCaT NHKs HaCaT
Keratinocytes laminin,
of fibronectin,
Response collagen collagen collagen collagen, serum calf fetal collagen collagen
Mechanotransduced Substrate N/A I Type Arginine I Type Arginine I Type IV Type arginine, I/IV Type I Type
17.2 14%–33% 10% 0.17Hz 15min–7days 10% 5min–24h 20% 24h 10% 5min 20% 15–30min 10% 5min–48h 10%–30% 1Hz 3min–24h 10% 0.17Hz 72h
TABLE Force Uniaxial Cyclic Strain: Uniaxial Static/cyclic Strain: Frequency: Period: Uniaxial Static Strain: Period: Uniaxial Static Strain: Period: Uniaxial Static Strain: Period: Uniaxial Static Strain: Period: Uniaxial Static Strain: Period: Uniaxial Static/cyclic Strain: Frequency: Period: Uniaxial Static/cyclic Strain: Frequency: Period:
II. MECHANOBIOLOGY AND TISSUE REGENERATION