Page 354 - Advances in Biomechanics and Tissue Regeneration

352 17. SKIN MECHANOBIOLOGY AND BIOMECHANICS: FROM HOMEOSTASIS TO WOUND HEALING

Reference [110] 113] [112, [111] [116] [121] [120] [119] [114] [124]

laminin

media to not

by synthesis but
mediated "Protein IV type

cells KCs pathways collagen

endothelial stimulated "Elongation pathway signaling receptor. 1 pathway pathway and pathway stress

response vascular human mechanically endothelium synthesis "DNA #PGE2 release signaling β1-integrins Akt and ERK1/2 type II angiotensin signaling signaling fibronectin to signaling β1-integrins stretch) (static stretch) (cyclic to perpendicular

Loading Mechanotransduced antagonist in "E-selectin by conditioned vascular "Proliferation #PKA Il-1 by Regulated ERK of Activation by Regulated influx "Calcium "Proliferation of Activation #K10 by Regulated Akt of Activation Antiapoptotic Akt of Activation Antiapoptotic adhesion Substrate ERK of Activation by Regulated protease protease Orientation area protease MMP-9

Tension "IL-1α "IL-1R Activate #cAMP "K6 " uPA # uPA " Reduced "

to
Subjected Cell KCs hNFKCs HaCaT NHK HaCaT NHK HaCaT NHKs HaCaT

Keratinocytes laminin,

of fibronectin,
Response collagen collagen collagen collagen, serum calf fetal collagen collagen

Mechanotransduced Substrate N/A I Type Arginine I Type Arginine I Type IV Type arginine, I/IV Type I Type

17.2 14%–33% 10% 0.17Hz 15min–7days 10% 5min–24h 20% 24h 10% 5min 20% 15–30min 10% 5min–48h 10%–30% 1Hz 3min–24h 10% 0.17Hz 72h

TABLE Force Uniaxial Cyclic Strain: Uniaxial Static/cyclic Strain: Frequency: Period: Uniaxial Static Strain: Period: Uniaxial Static Strain: Period: Uniaxial Static Strain: Period: Uniaxial Static Strain: Period: Uniaxial Static Strain: Period: Uniaxial Static/cyclic Strain: Frequency: Period: Uniaxial Static/cyclic Strain: Frequency: Period:

II. MECHANOBIOLOGY AND TISSUE REGENERATION