Page 355 - Advances in Biomechanics and Tissue Regeneration

PDMS,
[115]
[118]
keratinocytes;
human
normal
(primary)
NHKs,
cells;
B
activated
of
enhancer
#Differentiation
kappa-light-chain
layer
epidermal
IV/VII
"Proliferation
5
"Collagen
factor
"Laminin
Thicker
"AKT [117] (I) "BAD I) of 2days (after #Proliferation [125] 1 "Endothelin [122] coculture in HF and KCs of migration Asymmetric KCs not HF, from derived EGF by Regulated [16] keratin IL-α1, α6, integrin 1, endothelin 1, desmoglein 43, connexin β1, catenin E-cadherin, " MMP-9 11, fibronectin α5, laminin KGFR, 1/6/10/14, 17.3 SKIN MECHANOBIOLOGY membrane basement of Development [123] β1-integrin by mediated migration KC [126] mechanosensing in involved keratins and Desmosomes [20] (cyclic) #Proliferation pathway signal β1-CASK by Regulated skin; adult h
nuclear
adult fibroblasts; NF-κB,
hESCs or KCs epidermal available; proto-oncogene
NFKCs NHKs HF HaCaT HF HaCaT Neonatal foreskin HSE (NHK+HF) HaCaT HF HaCaT HaCaT EGF, human not PKB,
monophosphate; (primary) HF, N/A, A; kinase
fibronectin adenosine cells; stem metalloproteinase; protein
or cyclic embryonic MMP, PKA, E2;
collagen collagen collagen collagen collagen collagen collagen cAMP, receptor;
I I I I I I Arginine I human prostaglandin
Type Type PDMS Type Type Type Type Type death; from factor
cell PGE2,
of derived growth
(tension 0.17Hz 10%–20% 1Hz 24–48h 15%–30% 6days 0.2Hz 12–72h 0.5Hz 1–72h 0.03Hz 5days 6days 1Hz 6days BCL2-antagonist keratinocytes keratinocyte

Uniaxial Cyclic Intermittent +relaxation) 10% Strain: Frequency: Uniaxial Cyclic Strain: Frequency: Period: Uniaxial Static Strain: Period: Uniaxial Cyclic 20% Strain: Frequency: Period: Uniaxial Cyclic 10% Strain: Frequency: Period: Uniaxial Cyclic 10% Strain: Frequency: Period: Uniaxial Static 20% Strain: Period: Uniaxial Static 10% Strain: 5min Period: Uniaxial Static/cyclic 20% Strain: Frequency: Period: BAD, hESCs, KGFR, poly-dimethylsiloxane;

II. MECHANOBIOLOGY AND TISSUE REGENERATION