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280     Chapter 8/Statistical intervals for a single sample


               Figure 8-3 presents the histogram and normal probability plot of the mercury concentration data. Both plots indicate
               that the distribution of mercury concentration is not normal and is positively skewed. We want to i nd an approximate
               95% CI on μ. Because n > 40, the assumption of normality is not necessary to use in Equation 8-11. The required
                                                             .
                                   0
               quantities are n = 53, x = .5250 ,s  = .3486, and z 0 025.  =  1 96. The approximate 95% CI on μ is
                                             0
                                                 x −  z 0 .025  s  Ð μ ≤  x +  z .0 025  s
                                                          n              n
                                                      .
                                                                             .
                                                  .
                                           .
                                                −
                                                                       .
                                                                     +
                                          0 5250 1 96  0 3486  ≤ μ Ð . 0 5250 1 96  0 3486
                                                        53                    53
                                                       .
                                                      0 4311≤ μ ≤  0 6189
                                                                 .
                                                                  99
                                                                  95
                          9                                       90
                          8                                       80
                          7                                       70
                                                                  60
                          6                                     Percentage  50
                        Frequency  5                              30
                                                                  40
                          4
                                                                  20
                          3                                       10
                          2                                       5
                          1
                                                                  1
                          0
                             0.0       0.5       1.0       1.5            0.0        0.5        1.0
                                        Concentration                              Concentration
                                                                                      (b)
                                           (a)
               FIGURE 8-3  Mercury concentration in largemouth bass. (a) Histogram. (b) Normal probability plot.


                 Practical Interpretation: This interval is fairly wide because there is substantial variability in the mercury concentra-
               tion measurements. A larger sample size would have produced a shorter interval.



                                   Large-Sample Confi dence Interval for a Parameter

                                   The large-sample conidence interval for μ in Equation 8-11 is a special case of a more general
                                                                                           ˆ
                                   result. Suppose that θ is a parameter of a probability distribution, and let Θ be an estimator of θ.
                                     ˆ
                                   If Θ (1) has an approximate normal distribution, (2) is approximately unbiased for θ, and (3) has
                                                                                                ˆ
                                   standard deviation σ  that can be estimated from the sample data, the quantity (Θ  − 0) / σ  has an
                                                  Θ ˆ                                                  Θ ˆ
                                   approximate standard normal distribution. Then a large-sample approximate CI for θ is given by
                       Large-Sample
                       Approximate                          ˆ            ˆ
                                                                      θ
                         Coni dence                         θ − z α/ σ Θ ˆ ≤ ≤ θ + z α/ σ Θ ˆ       (8-12)
                                                                              2
                                                                 2
                           Interval
                                   Maximum likelihood estimators usually satisfy the three conditions just listed, so Equation 8-12
                                                  ˆ
                                   is often used when Θ is the maximum likelihood estimator of θ. Finally, note that Equation 8-12
                                   can be used even when σ ˆ  is a function of other unknown parameters (or of θ). Essentially, we
                                                      Θ
                                   simply use the sample data to compute estimates of the unknown parameters and substitute those
                                   estimates into the expression for σ ˆ .
                                                             Θ
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