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Fundamentals of Experimental Design  453


               We can see that for the original complete factorial experimental data set,
             the factorial effects are

                   A   3.8    B   5.5  C   1.2   AB    0.6    AC   0.9
                 BC   4.6   ABC    0.7

               Now, if we assume, for some reason, that we cannot obtain the complete
             data set for this experiment and some experimental data are missing, then
             how can we use Draper and Stoneman’s method to do the data analysis?
               Case 1:  One data point is missing    In this case, we assume that one data
             point is missing. For example, we can assume that the third response, m
             21.9, is missing. In Draper and Stoneman’s method, this missing observa-
             tion m will be estimated by assuming one of the factorial effects to be equal
             to zero. In a full factorial experiment, the most frequently used approach
             will be to assume the highest interaction to be zero. In this example, we will
             assume ABC   0. From the coefficients of the column ABC in Table 12.19,
             ABC   0 means that

                     21.1   16.3   m   17.3   16.1   14.5   27.5   23.3   0

               By solving this equation, we get m   24.7.
               In Draper and Stoneman’s method, this estimated missing value m   24.7
             will be put back in Table 12.19. We can see there is some difference between
             the actual value m   21.9 and estimated value m   24.7.
               The corresponding MINITAB output with estimated  m   24.7 is as
             follows:

             Factorial Fit: Y versus A, B, C

             Estimated Effects and Coefficients for Y (coded units)
             Term      Effect    Coef
             Constant          20.100
             A         -4.500  -2.250
             B          6.200   3.100
             C          0.500   0.250
             A*B       -1.300  -0.650
             A*C        1.600   0.800
             B*C        3.900   1.950
             A*B*C     -0.000  -0.000

               This result is somewhat different than what we get by using the actual
             value m   21.9, but we will probably derive the similar conclusion as if we
             used the actual data.
               In fractional factorial experiments, we usually cannot calculate the high-
             est interaction effect, so assuming the highest interaction effects to be zero
             is not a workable assumption. Also, even in full factorial experiments,
             assuming the highest interaction to be zero may not be the best approach,
             because in some experiments, we do have significant higher-order interaction
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