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            FIG. 9.2 Effect of number of grids (or grid size) on FMM and k-Wave simulations. Comparison of
            compressional wavefront travel time at each sensor calculated using the FMM, k-Wave, and ana-
            lytical method for Case #1, as shown in Fig. 9.1A, for four different numbers of grids. x-Axis rep-
            resents the distance between the source and the sensor/receiver; y-axis represents the wavefront
            travel time at receiver/sensor. (A) Number of grids: 50 by 50, (B) number of grids: 75 by 75,
            (C) number of grids: 100 by 100, and (D) number of grids: 500 by 500.

            by 150 mm (i.e., grid size of 0.3 mm by 0.3 mm). FMM only simulates the
            wavefront, and the FMM calculation process is fast and efficient for simple
            cases. k-Wave simulation quantifies the whole process of wave propagation
            resulting in the calculation of full waveform at the sensors. Based on our numer-
            ical experiments, when the number of grids is 500 by 500 for the material of
            dimension 150 mm by 150 mm, both k-Wave and FMM predictions of travel
            times coincide with the analytical solutions. In all subsequent numerical exper-
            iments and dataset generation, a grid number of 500 by 500 will be used to
            discretize the materials of any dimension (i.e., grid size smaller than 0.3 mm
            by 0.3 mm).

            3.2.2 Material with large contrasts in compressional wave velocity
            FMM simulation and other numerical simulations tend to be unstable and inac-
            curate in the presence of large contrasts in material properties. In this section, a
            numerical model of material dimension 150 mm by 300 mm is created with 60
            alternating layers that result in large contrasts (Fig. 9.4) and discretized using
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