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180   Cha p te r  E i g h t


                     case study from a real-life multipurpose batch facility is presented
                     next.


                       Example 8.3: Optimal Scheduling
                       The case study is taken from a multinational pharmaceuticals facility that
                       produces lotions, shampoos, conditioners, and various creams. The problem
                       features nonintermediate storage policy (NIS), and the processes involve
                       mixing and packaging. Mixing occurs in four mixing vessels (V1, V2, V3, and
                       V4), and packaging occurs in three packing lines (P1, P2, and P3). Because the
                       stirrers in mixing vessels are of different designs, mixing times vary according
                       to the vessel used. Table 8.4 shows the duration of mixing for each product
                       in each vessel, which have a capacity of about 3 t each. The table also lists
                       the economic contribution made to the company revenue or profit by selling
                       a unit of each product; shampoos have the highest economic contribution.
                       The packing duration for each product is 12 h, regardless of which packing
                       line is employed. The objective in this case study is to maximize the overall
                       economic result for a 24-h period. The S-graph for the recipe for the products
                       manufactured in this facility is given in Figure 8.12, where the sets of candidate
                       equipment units for performing tasks 1, . . . , 15 are defined by sets U1 = {V1, V2,
                       V4}, U2 = {P1, P2, P3}, U3 = {V1, V2, V3}, U4 = {V3}, U5 = {V2, V3}, and U6 = {V1,
                       V2, V4}.
                         The global optimal solution corresponds to two batches of Cream 2 and
                       one batch of Shampoo, which yields revenue of 9.5 cost units. The schedule
                       corresponding to the global optimum is shown in Figure 8.13.
                         Two advantages that this approach has over its Mathematical Programming
                       counterparts are: (1) it guarantees global optimality and (2) no manipulation
                       of the time horizon is required—in particular, it is unnecessary to presuppose
                       “time points” that will discretize the time horizon into equal (or unequal) time
                       intervals. For this reason, the technique qualifies as a true continuous-time
                       methodology.

                     8.5.2  Heat-Integrated Production Schedules
                     Many algorithmic and heuristic methods have been developed for
                     solving Heat Integration problems in continuous processes: Pinch
                     Technology (Linnhoff et al., 1982), superstructure-based mixed



                 Product     Economic        Production time in mixing vessel [h]
                             contribution [cost
                             unit/batch]     V1        V2       V3       V4
                 Cream 1     2               10        5        N/A      5
                 Cream 2     3               12        10       7        N/A
                 Conditioner  1              N/A       N/A      12       N/A
                 Shampoo     3.5             N/A       8        13       N/A
                 Lotion      1.5             10        6        N/A      9

                TABLE 8.4  Scheduling Data for the Case Study of Example 8.3
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